Studies have shown that CBD works differently from THC because it does not work through cannabinoid receptors. It does not have the same psychoactive effects as THC. In addition, CBD helps counteract the anxiety induced by THC because it works against THC’s CB1 receptors. Several studies have shown that CBD may have the potential to reduce spasms in people. Patients with multiple anti-inflammatory sclerosis in spinal cord injury may have potential therapeutic potential for Parkinson’s and cancer. There are also negative study findings when using low levels of CBD. Accepts many types of serotonin receptors Glycine Receptors and Receptors Affecting Calcium levels in cellular segments, high levels of CBD were able to activate TRVP1 and TRVP2, inhibiting AEA intracellular and AEA breakdown.
There is also a study on the pharmacological activity of CBD, and it was found that it can help prevent and treat the symptoms of various diseases as follows:
Analgesic effect: Oromucosal spray, Nabiximols, a combination of THC and CBD, has been formulated to help reduce rheumatoid arthritis, but for chronic pain in cancer patients, it is also effective. There is no clear clinical conclusion. To get an excellent product, you need an excellent CBD shop.
Helps control epilepsy. There have been animal trials using CBD, which is effective against seizures. (Anticonvulsant) and no neurotoxicity. Subsequently, clinical trials were conducted on patients who experienced uncontrollable seizures. When an anticonvulsant was given 200-300 mg of CBD daily for 8-18 weeks, 37% of the patients had no seizures throughout the study, and another 37% had a marked improvement. However, side effects have occurred in people taking CBD .is causing drowsiness.
Further research using CBD alone has allowed us to understand the mechanism of CBD action better. A clinical study of Epidolex® (GW Pharmaceuticals), which contains CBD as the active ingredient, found that it could be used to treat non-convulsive seizures. It can be controlled with intractable epilepsy, such as Dravet and Lennox-Gastaut syndromes, and was approved by the US FDA in November 2018 to treat both types of seizures.
Drug interactions with CBD. Effects on P-glycoprotein (P-GP), an efflux transporter that influences drug resistance in various cancers. CBD inhibits P-GP ATPase in several cancer cell lines. It inhibits the reflux of many cancer drugs, including methotrexate, tyrosine kinase inhibitors (e.g., dasatinib), taxanes (e.g., paclitaxel), and vinca-alkaloids (e.g., vincristine), topoisomerase inhibitors (e.g., irinotecan), intercalants (e.g., doxorubicin).
It affects a protein called breast cancer resistance protein (BCRP), which is associated with drug resistance in breast cancer by inhibiting it. It is effective against many cancer drugs, including methotrexate, cyclophosphamide, paclitaxel, topotecan, dasatinib, etc. You will get all the product in CBD shop.
Several CYP-mediated effects, such as CYP2C19 inhibitors, affect the metabolites of several drugs that use this enzyme, including cyclophosphamide, imatinib, and lapatinib. Therefore, the concomitant use of CBD with these CYP inhibitors, such as clobazam and diazepam, should be cautioned against dose reductions. Tamoxifen, gefitinib, and imatinib inhibit CYP3A4, which are highly effective for many drugs because many drugs are metabolized by this enzyme, including cyclophosphamide paclitaxel, anastrozole, dasatinib, etc.
Recommendations and practices
It has been suggested that pregnant women should not use CBD. Who is breastfeeding and psychiatric patients? In addition, the adverse reactions associated with CBD use in patients with DS include drowsiness, diarrhea, fatigue, vomiting, fever, and drowsiness. Similar symptoms have been reported in LGS patients, including drowsiness, when CBD doses are used. Hepatic enzyme levels elevated or in combination with other anticonvulsants, such as valproate and clobazam, were somewhat elevated. THERE WAS NO RESPIRATORY SUPPRESSION EFFECT when CBD was given with low-dose fentanyl. However, it was found that the high doses of fentanyl had only a slight reduction in respiratory rate and body temperature.
In addition, cannabis is considered an addictive substance. Therefore, it should be approved or prescribed by a doctor before being used. Hanfpost CBD shop in Switzerland provide you good quality products.